When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication ...

DNA replication is a fundamental process essential for bacterial growth and survival. Initiation begins at the chromosomal origin (oriC), where the conserved initiator protein DnaA assembles into an ...

Researchers have shown for the first time how Merkel cell polyomavirus (MCV), which causes an aggressive skin cancer called Merkel cell carcinoma, initiates DNA replication in host cells. University ...

Cancer isn't just about broken genes—it's about broken architecture. Imagine a city where roads suddenly vanish, cutting off ...

A closeup look at colibactin’s structure reveals chemical motifs that guide its mutation-wreaking “warheads” to specific stretches of DNA.

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Dr Liu is a ...

The Nobel prize in chemistry has gone to research showing how DNA fixes the damage that can cause cancer and premature ageing. Tomas Lindahl of the Francis Crick Institute in Hertfordshire, UK, Paul ...

EMBARGOED: A new study to be presented Dec. 6 at the 2025 American Society of Hematology (ASH) meeting reveals that even subtle disruptions in genome architecture can predispose individuals to ...

Scientists have created a live-cell DNA sensor that reveals how damage appears and disappears inside living cells, capturing ...

BIRMINGHAM, Ala. – BK polyomavirus, or BKPyV, is a major cause of kidney transplant failure. There are no effective drugs to treat BKPyV. Research at the University of Alabama at Birmingham reveals ...

The first 100 bases of many genes show excess mutations, revealing a major genomic weak spot that shapes disease risk and ...